Microglia and Neuroinflammation

Organised by Guy C. Brown, Jenny Pocock, and Jacob M. Dundee with the Biochemical Society

Meeting introduction

Guy C. Brown

Discussion session on microglial states and nomenclature

Chairs: Sandra Siegert, Bart Eggen, Michael Heneka, Marina Lynch, Jennifer Pocock

Discussion session on when neuroinflammation is good/bad

Chairs: Sandra Siegert, Bart Eggen, David Brough, Michael Heneka, Jennifer Pocock

Career session

Chairs: Jennifer Pocock,
Jacob M. Dundee, Michael Perkington, Svetlana Khoronenkova

Jacob Dundee

P2Y₆ receptor-dependent microglial phagocytosis of synapses during development regulates synapse density and memory

Dervis Salih

Genetic variation associated with human longevity and Alzheimer’s disease risk act through microglia and oligodendrocyte cross-talk

Marina Lynch

The interaction between sex, neuroinflammation and Alzheimer’s disease

Rommy von Bernhardi

Aging-dependent changes in microglia-neuron interaction and neuroinflammation

Umran Yaman

Synaptic adaptation via microglia Isoform alterations in APPNL-G-F knock-in mouse model of Alzheimer's Disease detected by long-read transcriptome analysis

Yaming Wang

Microglial mechanism in Alzheimer’s disease

Timothy Birkle

Disease phenotypic screening in neuron-glia co-cultures identifies blockers of inflammatory neurodegeneration

Richard Milner

Investigating the role of microglia in maintaining vascular integrity in the hypoxic central nervous system; the effect of age

Sheetal Sreeram

Studying cell-extrinsic regulators of HIV latency and microglia phenotypes in the brain

Amol Bhandare

Microglia modify development of breathing phenotype in chronic epilepsy

James Rowe

Microglial activation in AD, FTD, PSP

Michael Heneka

Neurons escape degeneration through tunnelling nanotube support by microglia

Andrea Ablasser

cGAS/STING drives ageing-related inflammation and neurodegeneration

Svetlana Khoronenkova

Mechanisms of neuroinflammation in genome instability

David Brough

Understanding and targeting inflammasomes in neuroinflammation

Peter St. George-Hyslop

Roles of microglial risk and resilience genes

Ryan Bevan

Uncoupling of synaptic loss from amyloid burden by an Alzheimer’s disease protective variant of PLCγ2

Charlie Arber

Microglia produce the amyloidogenic ABri peptide in familial British dementia

Radhika Joshi

Microglial IRF3 regulates neuroinflammation in acute inflammatory conditions and in Alzheimer’s disease

Anna-Sophia Hartke

The interplay of Lipopolysaccharide and alpha-Synuclein exacerbates neuroinflammation

Irini Evnouchidou

A new transcription factor regulating neuroinflammation

Vilmante Borutaite

Extracellular Tau-induced neuroinflammation and neuronal loss

Sandra Siegert

How to get from microglia cell shape to their function

Guy Brown

Microglial phagocytosis in pathology

Bart J.L. Eggen

Human microglia, from a developmental and pathological perspective

Jennifer Pocock

Stem cell-derived microglia in Alzheimer’s research

Bo Peng

Turnover and replacement: the philosophy of microglia

Rugile Matuleviciute

Diversity of transcript isoforms in developing hIPSC-derived microglia

Michael-John Dolan

Exposure of iPSC-derived human microglia to brain substrates enables generation and manipulation of diverse transcriptional states

Camilla Fairbairn

Rapid & consistent generation of functional microglia from hiPSCs to study mechanisms in neurodegeneration & neuroinflammation

Jörg Hamann

Microglia transcriptional profiling in major depressive disorder shows inhibition of cortical grey matter microglia

Closing remarks

Jennifer Pocock