Microglia and Neuroinflammation

PROGRAMME

Monday 18 September 2023

11:30 – 11:50 Opening introduction

Session 1 - Microglial identity and expression profiles (Chair: Guy Brown)

11:50 - 12:20   (S005) Human microglia, from a developmental and pathological perspective.
Bart J.L. Eggen - University Medical Center Groningen, University of Groningen, Netherlands

12:20 - 12:40   (OC001) Microglia transcriptional profiling in major depressive disorder shows inhibition of cortical grey matter microglia
Jörg Hamann - Amsterdam University Medical Centers, Netherlands

12:40 - 13:00   (OC002) Turnover and replacement: the philosophy of microglia
Bo Peng - Fudan University

Session 2 - Stem cell-derived microglia and applications (Angela Hodges)

14:00 - 14:30   (S006)  Stem cell-derived microglia in Alzheimer’s research
Jennifer Pocock - University College London, United Kingdom

14:30 - 14:50   (OC003) Diversity of transcript isoforms in developing hIPSC-derived microglia
Rugile Matuleviciute - King's College London, United Kingdom

14:50 - 15:10   (OC004) Exposure of iPSC-derived human microglia to brain substrates enables generation and manipulation of diverse transcriptional states
Michael-John Dolan - Broad Institute of MIT and Harvard, United States

15:10 - 15:30   (OC005) Rapid & consistent generation of functional microglia from hiPSCs to study mechanisms in neurodegeneration & neuroinflammation.
Camilla Fairbairn - bit.bio, United Kingdom

Session 3 - Microglial phagocytosis and pathology (Chair: Jenny Pocock)

16:00 - 16:30   (S007) Microglial phagocytosis in pathology
Guy Brown - University of Cambridge, United Kingdom

16:30 - 17:00   (S008) How to get from microglia cell shape to their function
Sandra Siegert - ISTA, Austria

17:00 - 17:30   (OC006) Extracellular Tau-induced neuroinflammation and neuronal loss
Vilmante Borutaite - Neuroscience Institute, Lithuanian University of Health Sciences, Lithuania

17:30 - 18:30. Careers session
Chairs: Jennifer Pocock, Jacob Dundee, Michael Perkington, Svetlana Khoronenkova

18:30 - 19:30.  Welcome Reception

Tuesday 19 September 2023

Session 4 - Neuroinflammation (Chair: Vilma Borutaite)

09:00 - 09:30   (S002) Roles of microglial risk and resilience genes
Peter St. George-Hyslop - Columbia University, United states

09:30 - 10:00   (S010) Understanding and targeting inflammasomes in neuroinflammation
David Brough - University of Manchester School of Biological Science: The University of Manchester Faculty of Biology Medicine and Health, United Kingdom

10:00 - 10:15   (OC009) A new transcription factor regulating neuroinflammation
Irini Evnouchidou - Centre de Recherche sur l'Inflammation, INSERM U1149-CNRS ERL8252, Université de Paris, France

10:00 - 10:15   (OC007) Microglial IRF3 regulates neuroinflammation in acute inflammatory conditions and in Alzheimer’s disease.
Radhika Joshi - BIDMC, United States

10:15 - 10:30   (OC008) The interplay of Lipopolysaccharide and alpha-Synuclein exacerbates neuroinflammation
Anna-Sophia Hartke - University of Veterinary Medicine Hannover, Germany

Session 5 - Microglial activation (Chair: Sandra Siegert)

11:00 - 11:30 (S012) cGAS/STING drives ageing-related inflammation and neurodegeneration
Andrea Ablasser - EPFL, Switzerland

11:30 - 12:00   (S003) Mechanisms of neuroinflammation in genome instability
Svetlana Khoronenkova - University of Cambridge, United Kingdom

12:00 - 12:15   (OC007) Microglial IRF3 regulates neuroinflammation in acute inflammatory conditions and in Alzheimer’s disease.
Radhika Joshi - BIDMC, United States

12:15 - 12:30   (OC010) Mechanistic insights into MOK, a new signaling kinase in microglia involved in neurodegenerative inflammation
Cintia Roodveldt - CABIMER-Center for Molecular Biology & Regenerative Medicine, University of Seville, Spain

Session 6 - Alzheimer’s and related dementias (Chair: Bart Eggen)

13:30 - 14:00   (S009) Neurons escape degeneration through tunnelling nanotube support by microglia
Michael Heneka - Université du Luxembourg, Luxembourg

14:00 - 14:15   (OC011) Microglia produce the amyloidogenic ABri peptide in familial British dementia
Charlie Arber - UCL Institute of Neurology, United Kingdom

14:15 - 14:30   (OC012) Uncoupling of synaptic loss from amyloid burden by an Alzheimer’s disease protective variant of PLCγ2
Ryan Bevan - UKDRI at Cardiff University, United Kingdom

14:30 – 15:00 Microglial activation in AD, FTD, PSP
James Rowe - University of Cambridge, United Kingdom

15:00 - 16:30 Poster Session with refreshments

16:30 - 17:00 Discussion session on microglial states and nomenclature
Chairs: Sandra Siegert, Bart Eggen, Michael Heneka, Marina Lynch, Jennifer Pocock

17:00 - 17:30 Discussion session on when neuroinflammation is good/bad
Chairs: Sandra Siegert, Bart Eggen, David Brough, Michael Heneka, Jennifer Pocock

17:30 - 19:00 Informal tour of Cambridge/Punting

19:00 - 21:00 Drinks Reception followed by Conference dinner

Wednesday 20 September 2023

Session 7 - Microglia in neurodenegration (Chair: Marina Lynch)

09:00 - 09:30  (S004) Exploring Alzheimer’s disease risk variants linked to microglia
Angela Hodges - King's College London, United Kingdom

09:30 - 09:50   (OC013) Microglia modify development of breathing phenotype in chronic epilepsy
Amol Bhandare - School of Life Sciences, University of Warwick, United Kingdom

09:50 - 10:10   (OC014) Synaptic adaptation via microglia
Umran Yaman - UK DRI at UCL, United Kingdom

10:10 - 10:30   (OC015) Studying cell-extrinsic regulators of HIV latency and microglia phenotypes in the brain
Sheetal Sreeram - Case Western Reserve University, United States

Session 8 - Microglial medicine (Chair: Hugh Nuthall)

11:00 – 11.30 Microglial mechanism in Alzheimer’s disease
Yaming Wang - Eli Lilly

11:30 - 11:50   (OC016) Human-derived CD33 antibody ATLX-1088 stimulates microglial pharmacology
Helen Graves - Alchemab Therapeutics, United Kingdom

11:50 - 12:10   (OC017) Disease phenotypic screening in neuron-glia co-cultures identifies blockers of inflammatory neurodegeneration
Timothy Birkle - University of Cambridge, United Kingdom

12:10 - 12:30   (OC018) Genetic variation associated with human longevity and Alzheimer’s disease risk act through microglia and oligodendrocyte cross-talk
Dervis Salih - UCL, United Kingdom

Session 9 - Microglial sex and ageing (Chair: Svetlana Khoronenkova)

13:30 - 14:00   (OC019) The interaction between sex, neuroinflammation and Alzheimer’s disease
Marina Lynch - Trinity College Dublin, Ireland

14:00 - 14:30   (OC020) Aging-dependent changes in microglia-neuron interaction and neuroinflammation
Rommy von Bernhardi - Universidad San Sebastian, Faculty For Health Care Sciences, Chile

14:30 - 14:45   (OC021) Investigating the role of microglia in maintaining vascular integrity in the hypoxic central nervous system; the effect of age
Richard Milner - San Diego Biomedical Research Institute, United States

14:45 - 15:00   (OC022) P2Y₆ receptor-dependent microglial phagocytosis of synapses during development regulates synapse density and memory
Jacob Dundee - University of Cambridge, United Kingdom

15:00 - 15:15 Closing Remarks